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A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: In particular, mouse Ly-6A/Sca-1 is a widely used marker for various stem cells; however, its human orthologproteins, we identified a previously unannotated human gene encoding the candidate ortholog of mouseThis gene, hereby named LY6A, reversely overlaps with a lncRNA gene in the majority of exonicCollectively, these studies unveil a novel human gene encoding a candidate biomarker and provide an interestingmodel gene for studying gene regulatory and evolutionary mechanisms.

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymous    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract:

The antibiotic resistance is natural in bacteria and predates the human use of antibiotics.However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicineregarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments, humanWe propose that the resistance gene flow in nature is “from the natural environments” and, contribute greatly to such a resistance gene “circulation.

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 280-289 doi: 10.1007/s11684-013-0265-3

Abstract:

Many gene fusions have been recognized as important diagnostic and/or prognostic markers in humanIn recent years, novel gene fusions have been identified in cases without prior knowledge of the geneticThis review focused on advanced genome-wide screening approaches in fusion gene identification, suchas microarray-based approaches, next-generation sequencing, and NanoString nCounter gene expression systemThe fundamental rationale and strategy for fusion gene identification using each biotech platform are

Keywords： gene fusion     cancer     microarray     next-generation sequencing     NanoString nCounter system    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: To date, four mutations in the GJB6 gene, G11R, V37E, A88V, and D50N, have been confirmed to causeIn previous studies, the focus has been mainly on gene sequencing, and there has been a lack of researchWe found a novel heterozygous missense variant (c.134G>C:p.G45A) for Clouston syndrome.Our data reveal that a novel variant (c.134G>C:p.G45A) plays a likely pathogenic role in this pedigree

Keywords： Clouston syndrome     whole exome sequencing     GJB6 gene     novel variant     unique phenotype    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract:

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achievedin liver-directed gene transfer mediated by adeno-associated viral vectors.Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-humanvectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B geneto obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: To determine whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induceantitumor immunity against tumor cells which express the gene, we constructed mouse tumor cells expressinghuman SART3 (LM8-SART3) and carried out experiments .After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredhuman SART3 (LM8-SART3) which may provide new possibilities in antitumor therapy.

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 275-276 doi: 10.1007/s11684-013-0285-z

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a novel K+ transporter gene in cotton

Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 226-235 doi: 10.15302/J-FASE-2017170

Abstract: This study, identified a K transporter gene, expressed in the roots of cotton ( ) cv.

Keywords： cotton     GhKT2     potassium     transporter     uptake    

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A novel aldo-keto reductase gene,

Jinxi HUO, Bing DU, Sifan SUN, Shaozhen HE, Ning ZHAO, Qingchang LIU, Hong ZHAI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 206-213 doi: 10.15302/J-FASE-2018225

Abstract: In this study, the gene was isolated from sweet potato.

Keywords： cadmium stress     IbAKR     Ipomoea batatas     sweet potato    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functionof human genetic diseases carried out in the National Laboratory of Medical Genetics of China, werechromosome t (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and humanIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of &actinic porokeratosis (DSAP) was identified at Chromosome 12q23. 2 - 24. 1; and at the same year a novel

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 93-98 doi: 10.1007/s11684-007-0018-2

Abstract: lymphomas and reactive lymph node hyperplasia, and to perform an initial bioinformatic analysis on a novelgene, KIAA0372, which is highly expressed in the LNC of lymphomas. mRNA extracted from LNC of lymphomasand reactive lymph node hyperplasia were respectively marked with biotin and hybridized with Gene ExpressionInitial bioinformatic analysis was then performed on a novel gene named KIAA0372, whose function hasUsing Gene Expression Chips, many differentially expressed genes were uncovered.

Keywords： bioinformatic analysis     functional     KIAA0372     detection     Microarray    

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Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Frontiers of Engineering Management 2016, Volume 3, Issue 1,   Pages 30-38 doi: 10.15302/J-FEM-2016008

Abstract: Frequent traffic accidents constitute a major danger to human beings.Affymetrix Genome-Wide Human Mapping SNP 6.0 Array.The authors observed that the gene frequencies of 34 single-nucleotide polymorphisms (SNPs) in threeThe results indicated that SNP rs6069499 within linked CBLN4 gene are strongly associated with accidentAccording to CBLN4 gene mainly involved in adrenal development and the regulation of secretion, the authors

Keywords： accident proneness     genome-wide association study (GWAS)     dopamine (DA)     ACTH     susceptibility gene     traffic    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines(human hepatoma cell line HepG2, human colon cancer cell line LoVo, and human gastric cancer cell lineAGS) and nontumor cell lines (human embryonic liver cell line L02 (L02 cells) and human embryonic kidney293 cells [HEK293 cells]) as controls. 1395-bp-promoter fragment of XAF1 gene was amplified by polymerase

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulantpotential for adeno-associated virus (AAV)-delivered gene therapy was developed.Plasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)In conclusion, the application of the hybrid FVIII (hHC+ rLC) via an AAV-delivered gene therapy substantiallyThese data might be of help to the development of optimized FVIII expression cassette for HA gene therapy

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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Title Author Date Type Operation

A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Journal Article

a novel K+ transporter gene in cotton

Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI

Journal Article

A novel aldo-keto reductase gene,

Jinxi HUO, Bing DU, Sifan SUN, Shaozhen HE, Ning ZHAO, Qingchang LIU, Hong ZHAI

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Journal Article

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Journal Article